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KMID : 0378019870300050063
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New Medical Journal
1987 Volume.30 No. 5 p.63 ~ p.67
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Effect of Calcium Antagonist on Function of Isolated Perfused Rabbit Kidney
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이권행/Lee, Kweon Haeng
이석용/김옥녀/이상복/조규철/Lee, Seok Yong/Lee, Ok Nyu/Kim, Sang Bok/Lee, Kyu Chul
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Abstract
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It is well known that calcium channel blocking agents inhibit voltage operated calcium channel. These agents show not only cardiovascular effects but also diuretic effects.
The purpose of these experiments was to determine the effects of calcium antagonist, diltiazem, on the renal function of isolated perfused rabbit kidney.
Significant increase of urine volume, sodium and chloride excretion rates, but not potassium, occtxred 10 minutes after diltiazem (0.1 μM) administration to the perfusate. At this concentration of diltiazem the vessel resistance of isolated perfused kidney had no change. The administration of diltiazem (1 uM) produced renal vasodilation and diuretic action. Thereafter renal effects of diltiazem had parallel relationship with dose. The diuretic effects of 10 μM and 100 μM of diltiazem showed no significant differences, probably near maximal diuretic effects of diltiazem occures at 10 UM in the perfusate.
Above results suggest that calcium antagonist, diltiazem, has direct diuretic properties through not only vasodilation of renal vessels but also effects on the tubular electrolyte exchange in the isolated perfused rabbit kidney.
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